Inflammation in atherosclerosis: Lessons and therapeutic implications
- PlaqueTec
- Oct 29
- 1 min read
A recent review by Prof Peter Libby and Prof Oliver Soehnlein “Inflammation in atherosclerosis: Lessons and therapeutic implications,” published in the journal Immunity, highlights that inflammation drives all stages of atherosclerosis, from lesion initiation to plaque rupture, through diverse immune cell populations.
These mechanistic insights closely align with PlaqueTec’s strategy of intra-coronary sampling coupled with omics technologies, OCT imaging and high-dimensional cell phenotyping. By characterising the inflammatory environment adjacent to coronary lesions, we're able to capture cell- and protein-specific signatures that systemic biomarkers may miss.
Through this approach, we're improving the understanding of the pathobiology of atherosclerosis – the most common cause of coronary artery disease – to identify novel endotype-specific biomarkers and pioneer a precision medicine approach to improve outcomes for millions of patients.
Libby, P. and Soehnlein, O. (2025). ‘Inflammation in atherosclerosis: Lessons and therapeutic implications’, Immunity, 58(10), pp. 2383–2401. doi: 10.1016/j.immuni.2025.09.012.
